Hume's arguments seem directed at Descartes. Hume argues that man gains knowledge from experience and that we should be skeptical of all other knowledge. Descartes believes all knowledge comes from the mind, and that the only thing we cannot question is our existence "I think, therefore I am." For Descartes, nothing else can be proven. Hume counters with:
Going from a molecular to an atomic level, we can describe much more of what exactly water "is." In the final analysis, however, we find that the electrons which account, at least partially, for every characteristic of water fail to find definition, or a form. The only way to describe the multidimensional orbitals of electrons in water is through probability theory. History has seen the failure of the plum-pudding model, Bohr's orbital model, and every other definite model for the circulation of electrons. The only theory which adequately accounts for electron circulation in water, and thus, as a result, for all its more broadly recognized properties, is probability theory. Probability theory is, by the way, a method of saying, "We don't know!?"
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